Kato T, Morita A, Matsumoto Y
Department of Radiology, Nagoya City University Medical School, Japan.
J Dermatol Sci. 1997 Jan;14(1):20-8. doi: 10.1016/s0923-1811(96)00544-0.
To investigate cerebral lesions in patients with antiphospholipid antibodies only complaining of mild headaches, but without any neurological abnormalities or abnormal computerized tomography or magnetic resonance imaging findings, brain single photon emission computerized tomography (SPECT) using N-isopropyl-p-[123I] iodoamphetamine was employed as a sensitive method. Focal low perfusion areas and/or non-uniform radioisotope uptake could be shown on brain SPECT in all patients. Quantification of cerebral blood flow with a microsphere method revealed decreased cerebral blood flow. Hypoperfusion areas might be caused by microarterial thrombosis, microvenous thrombosis or vascular spasms. Early detection of cerebral abnormalities allows steps to be taken to protect against irreversible progress of cerebral blood flow. Therefore, brain SPECT should be performed in patients with antiphospholipid antibodies.
为了研究仅主诉轻度头痛但无任何神经学异常或计算机断层扫描或磁共振成像异常发现的抗磷脂抗体患者的脑病变，采用使用N-异丙基-p-[123I]碘安非他明的脑单光子发射计算机断层扫描（SPECT）作为一种敏感方法。所有患者的脑SPECT均显示有局灶性低灌注区和/或放射性同位素摄取不均匀。用微球法对脑血流量进行定量分析显示脑血流量减少。低灌注区可能由微动脉血栓形成、微静脉血栓形成或血管痉挛引起。早期发现脑异常可采取措施防止脑血流的不可逆进展。因此，抗磷脂抗体患者应进行脑SPECT检查。
