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芳基呋喃衍生物的研究——第六部分。某些6-(5-芳基-2-呋喃基)-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑和6-(5-硝基-2-呋喃基)-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑的合成、表征及抗菌活性

Studies on arylfuran derivatives-Part VI. Synthesis, characterization and antibacterial activities of some 6-(5-aryl-2-furyl)-1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles and 6-(5-nitro-2-furyl)-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles.

作者信息

Holla B S, Shivananda M K, Akberali P M, Baliga S, Safeer S

机构信息

Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, India.

出版信息

Farmaco. 1996 Dec;51(12):785-92.

PMID:9050211
Abstract

A series of 4-[5-aryl-2-furfurylidene]amino-3-mercapto-5-substituted-1,2,4-tri azoles and 4-[5-Nitro-2-furfurylidene]amino-3-mercapto-5-substituted-1,2,4-tr iazoles have been synthesized and were converted into 1,2,4-triazolo [3,4-b]-1,3,4-thiadiazoles. These triazolothiadiazoles are also synthesized by an alternative method in better yields employing arylfuroic acids and s-triazoles in the presence of phosphorus oxychloride. The newly synthesized compounds are screened for their antibacterial properties.

摘要

一系列4-[5-芳基-2-糠叉基]氨基-3-巯基-5-取代-1,2,4-三唑和4-[5-硝基-2-糠叉基]氨基-3-巯基-5-取代-1,2,4-三唑已被合成，并被转化为1,2,4-三唑并[3,4-b]-1,3,4-噻二唑。这些三唑并噻二唑也通过另一种方法以更高的产率合成，该方法是在三氯氧磷存在下使用芳基糠酸和s-三唑。对新合成的化合物进行了抗菌性能筛选。

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