Narasimhan B, Peppas N A
Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283, USA.
J Pharm Sci. 1997 Mar;86(3):297-304. doi: 10.1021/js960372z.
Dissolution-controlled drug delivery systems are characterized by a phase erosion of the polymer carrier that is associated with fast or slow dissolution of the macromolecular chains. The molecular nature of the dissolution phenomenon was examined by analyzing the water transport process and the subsequent polymer chain disentanglement that is usually characterized by a snake-like motion of the chain (reptation). The results indicate that the polymer molecular weight, water, polymer and drug diffusion coefficients, equilibrium water concentration in the polymer, and water-polymer interaction parameter can control the mechanism and rate of drug release. A new model for this process was developed, and its predictions are compared with experimental studies of drug delivery from poly(vinyl alcohol)-based systems.
溶出控制型药物递送系统的特征在于聚合物载体的相侵蚀，这与大分子链的快速或缓慢溶解相关。通过分析水传输过程以及随后通常以链的蛇形运动（蠕动）为特征的聚合物链解缠结，研究了溶解现象的分子本质。结果表明，聚合物分子量、水、聚合物和药物的扩散系数、聚合物中的平衡水浓度以及水-聚合物相互作用参数可以控制药物释放的机制和速率。为此过程开发了一个新模型，并将其预测结果与基于聚乙烯醇系统的药物递送实验研究进行了比较。
