Radetti G, Paganini C, Antoniazzi F, Pasquino B, Valentini R, Gentili L, Tato L
Department of Paediatrics, Regional Hospital of Bolzano, Italy.
Horm Res. 1997;47(3):110-5. doi: 10.1159/000185444.
Growth hormone binding proteins, insulin-like growth factor I and insulin-like growth factor binding proteins were determined in 54 children and adolescents affected by type 1 diabetes mellitus (25 prepubertal and 29 pubertal) showing reduced height velocity and the results were compared to those of 104 matched controls. Growth hormone binding proteins were similar in prepubertal and pubertal subjects but were significantly lower in the prepubertal diabetic group than in controls. Insulin-like growth factor I was low both in prepubertal and pubertal diabetic subjects. Insulin-like growth factor binding protein 3 was similar to controls, while insulin-like growth factor binding protein 1 and 2 were always high in diabetic children. Insulin-like growth factor binding protein 4 was high only in the prepubertal diabetic group. In conclusion, a low insulin-like growth factor I in diabetic children seems to depend on a GH receptor and/or a postreceptor defect. A low insulin-like growth factor I together with a normal insulin-like growth factor binding protein 3 and high levels of insulin-like growth factor binding proteins 1, 2 and 4 results in a reduced bioavailability of insulin-like growth factor I to target tissues. This could be a possible contributing factor to the reduced height velocity seen in our diabetic children.
对54名身高增长速度减缓的1型糖尿病患儿及青少年（25名青春期前儿童和29名青春期儿童）进行了生长激素结合蛋白、胰岛素样生长因子I及胰岛素样生长因子结合蛋白的检测，并将结果与104名匹配的对照组进行比较。青春期前和青春期受试者的生长激素结合蛋白相似，但青春期前糖尿病组的生长激素结合蛋白显著低于对照组。青春期前和青春期糖尿病受试者的胰岛素样生长因子I均较低。胰岛素样生长因子结合蛋白3与对照组相似，而糖尿病患儿的胰岛素样生长因子结合蛋白1和2始终较高。胰岛素样生长因子结合蛋白4仅在青春期前糖尿病组中较高。总之，糖尿病患儿胰岛素样生长因子I水平较低似乎取决于生长激素受体和/或受体后缺陷。胰岛素样生长因子I水平较低，同时胰岛素样生长因子结合蛋白3正常，以及胰岛素样生长因子结合蛋白1、2和4水平较高，导致胰岛素样生长因子I对靶组织的生物利用度降低。这可能是导致我们研究中的糖尿病患儿身高增长速度减缓的一个潜在因素。
