Hamm B, Mahfouz A E, Taupitz M, Mitchell D G, Nelson R, Halpern E, Speidel A, Wolf K J, Saini S
Institut für Rontengendiagnostik, Universittsklinikum Charité, Humboldt-Universität zu Berlin, Germany.
Radiology. 1997 Mar;202(3):677-82. doi: 10.1148/radiology.202.3.9051015.
To compare dynamic gadolinium-enhanced with unenhanced magnetic resonance (MR) imaging in detection of liver metastases.
Two groups of patients were prospectively examined with unenhanced and dynamic gadolinium-enhanced MR imaging. The first group (n = 48) had proved liver metastases; the second group (n = 49) did not. One set of unenhanced and one set of gadolinium-enhanced MR images were selected per patient. Three independent, blinded readers assessed the images for presence, number, location, and conspicuity of lesions. Data were analyzed with receiver operating characteristic curves, and contrast-to-noise ratios were calculated for the images.
There was no statistically significant difference between the use of unenhanced and gadolinium-enhanced MR images in the differentiation of patients with from patients without metastases. The numbers of false-positive and false-negative diagnoses of individual lesions were higher (not statistically significant) with dynamic MR images than with unenhanced MR images. At dynamic MR imaging, contrast-to-noise ratio was highest in the early phase (30 seconds after injection of the contrast agent) but was not significantly different from the contrast-to noise ratio of the T2-weighted images.
Dynamic gadolinium-enhanced MR imaging showed no improvement over unenhanced MR imaging in detectability of liver metastases.
比较动态钆增强磁共振成像（MR）与非增强磁共振成像在检测肝转移瘤方面的效果。
前瞻性地对两组患者进行非增强和动态钆增强磁共振成像检查。第一组（n = 48）已证实存在肝转移瘤；第二组（n = 49）未发现肝转移瘤。每位患者选取一组非增强磁共振图像和一组钆增强磁共振图像。由三位独立的、不知情的阅片者评估图像中病变的存在、数量、位置及清晰度。采用受试者操作特征曲线分析数据，并计算图像的对比噪声比。
在区分有转移瘤和无转移瘤的患者时，使用非增强磁共振图像与钆增强磁共振图像之间无统计学显著差异。动态磁共振图像对单个病变的假阳性和假阴性诊断数量高于（无统计学显著差异）非增强磁共振图像。在动态磁共振成像中，对比噪声比在早期（注射造影剂后30秒）最高，但与T2加权图像的对比噪声比无显著差异。
在肝转移瘤的可检测性方面，动态钆增强磁共振成像相比非增强磁共振成像并无改善。
