Ahluwalia A, Cellek S
Cruciform Project, University College London, Rayne Institute, UK.
Curr Opin Nephrol Hypertens. 1997 Jan;6(1):74-9. doi: 10.1097/00041552-199701000-00014.
The control of the cardiovascular system is now known to involve a diversity of both humoral and neuronal mechanisms. With the advancement of immunohistochemical electrophysiological and microscopy techniques it has become clear that the nervous control of the cardiovascular system comprises several transmitters other than the classical autonomic neurotransmitters. These non-adrenergic non-cholinergic transmitters include substance P, calcitonin gene-related peptide and nitric oxide. These particular substances play important roles in the control of vascular tone and altered activity of these mediators contribute to several cardiovascular disease states. In the light of this there is considerable interest in exploiting these mediators as potential targets for therapeutic intervention.
现在已知心血管系统的控制涉及多种体液和神经机制。随着免疫组织化学、电生理学和显微镜技术的进步，很明显心血管系统的神经控制除了经典的自主神经递质外还包括几种递质。这些非肾上腺素能非胆碱能递质包括P物质、降钙素基因相关肽和一氧化氮。这些特定物质在血管张力的控制中起重要作用，这些介质活性的改变会导致几种心血管疾病状态。鉴于此，人们对将这些介质作为治疗干预的潜在靶点有相当大的兴趣。
