Abad J C, Talamo J H, Vidaurri-Leal J, Cantu-Charles C, Helena M C
Cornea Service, MEE1/Harvard Medical School, Boston, Massachusetts, USA.
J Cataract Refract Surg. 1996 Dec;22(10):1427-33. doi: 10.1016/s0886-3350(96)80142-8.
To compare 18% ethanol versus mechanical epithelial debridement in a group of patients having photorefractive keratectomy (PRK) for low to moderate myopia or astigmatism.
Hospital San Jose de Monterrey, Mexico.
This prospective, paired study comprised 18 patients who had bilateral PRK between June 1994 and March 1995. One eye had ethanol (alcohol) debridement and the other, mechanical. Time between PRKs was about 6 months. The two groups (alcohol versus mechanical) were compared for rate of re-epithelialization, refractive outcome, improvement in uncorrected visual acuity (UCVA), subjective haze grading, and loss of best corrected visual acuity (BCVA).
There was a nonsignificant trend in the alcohol-treated eyes toward a more rapid visual recovery. One week after PRK, 76% in the alcohol group but only 31% in the mechanical group had a UCVA of 20/40 or better. There were no significant between-group differences in rate of re-epithelialization, refractive outcome, subjective haze grading, and loss of BCVA.
Chemical de-epithelialization with dilute ethanol appears to be a simple, safe, and effective alternative to mechanical scraping before PRK and might promote faster visual rehabilitation.
在一组接受准分子激光角膜切削术（PRK）治疗低度至中度近视或散光的患者中，比较18%乙醇与机械性上皮清创术的效果。
墨西哥蒙特雷圣何塞医院。
这项前瞻性配对研究纳入了1994年6月至1995年3月期间接受双侧PRK的18例患者。一只眼睛采用乙醇（酒精）清创术，另一只眼睛采用机械清创术。两次PRK之间的时间间隔约为6个月。比较两组（乙醇组与机械组）的上皮再形成率、屈光结果、未矫正视力（UCVA）改善情况、主观 haze分级以及最佳矫正视力（BCVA）丧失情况。
乙醇治疗组的眼睛在视觉恢复方面有更快的趋势，但差异无统计学意义。PRK术后1周，乙醇组76%的患者UCVA达到20/40或更好，而机械组仅为31%。两组在上皮再形成率、屈光结果、主观 haze分级以及BCVA丧失方面无显著差异。
在PRK术前，用稀释乙醇进行化学性上皮清创术似乎是一种简单、安全且有效的替代机械刮除的方法，可能会促进更快的视觉康复。
