Wakasa K, Haba T, Hamada T, Sasaki M, Sakurai M
Department of Pathology, Osaka City University Hospital, Japan.
Pathol Int. 1997 Jan;47(1):54-9. doi: 10.1111/j.1440-1827.1997.tb04434.x.
The pathological features of 11 nodules of early hepatocellular carcinoma (EHCC) were studied. Their macroscopic features resembled those of adenomatous hyperplasia and differed from those of advanced hepatocellular carcinomas (AHCC). The EHCC extended along the hepatic lobular structure and lacked expansive growth. The endothelial cells in the sinusoids of EHCC did not react to Ulex europaeus agglutinin 1 (UEA1) like adenomatous hyperplasia or other liver parenchyma, whereas the endothelial cells in the AHCC did react to UEA1. Immunohistochemically, CD68-positive Kupffer cells were noted in the sinusoids of EHCC, whereas in the AHCC Kupffer cells were not seen. Tumor emboli in the portal vein and intrahepatic metastases were not identified in EHCC, which seemed to be carcinoma-in-situ or a microinvasive stage of hepatocarcinogenesis.
对11个早期肝细胞癌（EHCC）结节的病理特征进行了研究。其大体特征类似于腺瘤样增生，与进展期肝细胞癌（AHCC）不同。EHCC沿肝小叶结构延伸，缺乏膨胀性生长。EHCC肝血窦内的内皮细胞不像腺瘤样增生或其他肝实质那样对荆豆凝集素1（UEA1）产生反应，而AHCC中的内皮细胞对UEA1有反应。免疫组织化学显示，EHCC肝血窦中有CD68阳性的库普弗细胞，而在AHCC中未见库普弗细胞。在EHCC中未发现门静脉肿瘤栓子和肝内转移，这似乎是肝癌发生的原位癌或微浸润阶段。
