Andrén-Sandberg A, Dervenis C, Lowenfels B
Dept. of Surgery, Lund University Hospital, Sweden.
Scand J Gastroenterol. 1997 Feb;32(2):97-103. doi: 10.3109/00365529709000177.
In all forms of pancreatitis there appears to be a cellular dysfunction, glandular destruction, and, presumably, increased cell turnover. Increased cell division has been suggested as a potential precursor of cancer in many organs. The excess risk of pancreatic cancer that has been documented in epidemiologic studies in patients with various types of pancreatitis is consistent with this hypothesis. The uncertainties in epidemiologic studies notwithstanding, the existence of a clear association between pancreatitis and the subsequent risk of pancreatic cancer is found too often to be only randomized. The clinical relevance of a causal relationship between chronic pancreatitis and pancreatic cancer is, however, limited, since the prognosis of chronic pancreatitis cannot be separated from that of chronic alcoholism.
在所有类型的胰腺炎中，似乎都存在细胞功能障碍、腺泡破坏，并且推测细胞更新增加。在许多器官中，细胞分裂增加被认为是癌症的潜在先兆。各类胰腺炎患者的流行病学研究中所记录的胰腺癌额外风险与这一假说相符。尽管流行病学研究存在不确定性，但胰腺炎与随后发生胰腺癌风险之间存在明确关联的情况太过常见，不可能只是随机现象。然而，慢性胰腺炎与胰腺癌之间因果关系的临床相关性有限，因为慢性胰腺炎的预后无法与慢性酒精中毒的预后区分开来。
