Effect of methionine on the brain biogenic monoamines and on the cortical bioelectrical activity of rabbits.

Methionine (150 and 300 mg/kg ip for 3 days) did not change the concentrations of striatal DA. It was also without effect on the levels of NA and 5-HT in the diencephalon and in the brain stem, while the 5-HIAA content was significantly increased in both structures after the dose 300 mg/kg. The single injection of methionine in doses of 10--300 mg/kg iv provoked dose-dependent changes in cortical bioelectrical activity. It was observed a considerable increase in the number of spindles, an increase in the amplitude and number of waves composing the spindles as well as a rise in their frequency characteristic.