Rakasz E, Sandor M, Hagen M, Lynch R G
Department of Pathology, The University of Iowa, College of Medicine, Iowa City 52242, USA.
Immunol Lett. 1996 Dec;54(2-3):129-34. doi: 10.1016/s0165-2478(96)02662-4.
The epithelium of the murine vagina contains a resident population of gamma delta T-cells that expresses a homogenous Vgamma4/Vdelta1 TCR lacking N-region junctional diversity, implying that these T-cells recognize a very limited array of antigenic structures. The vaginal gamma delta T-cells express a pattern of surface markers characteristic of memory/effector T-cells that have previously been activated. Although vaginal gamma delta T-cells do not express the major costimulatory molecules CD28 and CD2, they do proliferate in response to a systemically delivered anti gamma delta TCR stimulus. Vaginal gamma delta T-cells contain mRNA that encodes the keratinocyte growth factor raising the possibility that these cells play a role in the repair of vaginal epithelium following injury. While the antigen recognized by the vaginal gamma delta TCR is unknown, a model is proposed which attempts to relate some of the unusual phenotypic features of vaginal gamma delta T-cells to the physiological injury and shedding of vaginal epithelium that occurs during the estrous cycle.
小鼠阴道上皮含有一群常驻γδ T细胞，这些细胞表达缺乏N区连接多样性的同质Vγ4/Vδ1 TCR，这意味着这些T细胞识别的抗原结构种类非常有限。阴道γδ T细胞表达出先前已被激活的记忆/效应T细胞特有的表面标志物模式。虽然阴道γδ T细胞不表达主要的共刺激分子CD28和CD2，但它们确实会对全身递送的抗γδ TCR刺激作出增殖反应。阴道γδ T细胞含有编码角质形成细胞生长因子的mRNA，这增加了这些细胞在阴道上皮损伤后修复中发挥作用的可能性。虽然阴道γδ TCR识别的抗原尚不清楚，但提出了一个模型，试图将阴道γδ T细胞的一些不寻常表型特征与发情周期中发生的阴道上皮生理损伤和脱落联系起来。
