Openshaw H, Slatkin N E, Smith E
Department of Neurology, City of Hope National Medical Center, Duarte, CA, USA.
Bone Marrow Transplant. 1997 Mar;19(5):503-5. doi: 10.1038/sj.bmt.1700679.
After 582 allogeneic bone marrow transplants, we have encountered four patients (0.7%) who developed transient unilateral or bilateral sixth nerve palsies. Three of the four patients also had bilateral ptosis. These signs resolved 24-48 h after cyclosporin and ganciclovir were discontinued. One patient had MRI T2 abnormalities compatible with cyclosporin neurotoxicity. We postulate that cyclosporin, possibly together with ganciclovir, can produce transient brain stem or neuromuscular dysfunction with eye movement abnormality in occasional patients.
在582例异基因骨髓移植后，我们遇到了4例患者（0.7%）出现短暂性单侧或双侧展神经麻痹。这4例患者中有3例还伴有双侧上睑下垂。停用环孢素和更昔洛韦后24 - 48小时，这些症状消失。1例患者的MRI T2异常符合环孢素神经毒性表现。我们推测，环孢素可能与更昔洛韦共同作用，在少数患者中可导致伴有眼球运动异常的短暂性脑干或神经肌肉功能障碍。
