主动回避条件反射后大鼠脑内神经节苷脂的变化。

Changes in rat brain gangliosides following active avoidance conditioning.

作者信息

Savaki H E, Levis G M

出版信息

Pharmacol Biochem Behav. 1977 Jul;7(1):7-12. doi: 10.1016/0091-3057(77)90004-1.

Abstract

Brain gangliosides of rats trained in a conditioned avoidance Sidman task and undisturbed rats in their cages were studied. The (14C) acetate was injected intracerebrally seven days before the starting of 30 days training. Thirty-seven days after injection all rats were killed and ganglioside fractions were isolated from neocortex, hippocampus, brain stem, cerebellum and residual cerebral tissue of each one brain. Trained rats had higher levels of (14C)-labeled polysialogangliosides (G1, G2, G3) in hippocampus and neocortex than the controls. Regarding the rest of the brain areas, a significant increase of G2 in the residual cerebral tissue of the trained as compared with the controls was found. The results suggest that the sialic acid rich gangliosides of only certain parts of the brain are affected by the Sidman avoidance conditioning of the animals.

摘要

对在条件性回避西曼任务中接受训练的大鼠以及关在笼中未受干扰的大鼠的脑苷脂进行了研究。在30天训练开始前7天，将（14C）醋酸盐脑内注射。注射37天后，处死所有大鼠，从每只大鼠的新皮质、海马体、脑干、小脑和剩余脑组织中分离出脑苷脂组分。训练后的大鼠海马体和新皮质中（14C）标记的多唾液酸脑苷脂（G1、G2、G3）水平高于对照组。对于其余脑区，发现训练组大鼠剩余脑组织中的G2与对照组相比有显著增加。结果表明，仅大脑某些部位富含唾液酸的脑苷脂会受到动物西曼回避条件作用的影响。