Chen Z, Sugimoto Y, Kamei C
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
Methods Find Exp Clin Pharmacol. 1995 Dec;17(10):669-75.
Effects of intracerebroventricular injection of histamine and its related compounds on rectal temperature were studied in mice. Histamine (0.1-1.0 mu g) and histidine (500-1,000 mg/kg) caused a dose-related hypothermia. H1 agonist, 2-methylhistamine and 2-thiazolylethylamine also displayed a dose-dependent hypothermia. In addition, H2 agonists, 4-methylhistamine and dimaprit elicited a decrease in body temperature. Preinjection of not only H1-antagonists (diphenhydramine and chlorpheniramine) but also H2 antagonists (cimetidine and ranitidine) abolished histamine-induced hypothermia. Either intracerebroventricular or intraperitoneal injection of thioperamide, a histamine H3 antagonist, showed hypothermia. The hypothermic effect produced by intracerebroventricular injection of thioperamide was significantly blocked by (R)-alpha-methylhistamine, a selective H3 agonist. In addition, the effect induced by thioperamide was inhibited by H1 and H2 antagonists, indicating that the H3 receptor also participates in histamine-induced hypothermia.
研究了向小鼠脑室内注射组胺及其相关化合物对直肠温度的影响。组胺（0.1 - 1.0μg）和组氨酸（500 - 1000mg/kg）引起剂量相关的体温过低。H1激动剂2 - 甲基组胺和2 - 噻唑基乙胺也表现出剂量依赖性的体温过低。此外，H2激动剂4 - 甲基组胺和二甲双胍引起体温下降。不仅预先注射H1拮抗剂（苯海拉明和氯苯那敏），而且预先注射H2拮抗剂（西咪替丁和雷尼替丁）都能消除组胺诱导的体温过低。组胺H3拮抗剂硫代酰胺脑室内或腹腔内注射均显示体温过低。脑室内注射硫代酰胺产生的体温过低效应被选择性H3激动剂（R）-α-甲基组胺显著阻断。此外，硫代酰胺诱导的效应被H1和H2拮抗剂抑制，表明H3受体也参与组胺诱导的体温过低。
