Toth T I, Crunelli V
Physiology Unit, School of Molecular and Medical Biosciences, University of Wales Cardiff, U.K.
Neuroscience. 1996 Mar;71(2):367-9. doi: 10.1016/0306-4522(95)00456-4.
In this paper, we have carried out a theoretical analysis of the recovery process of inactivating currents whose voltage-dependent conductances obey the Hodgkin-Huxley equations. We demonstrate that the recovery process is complex, and, in particular, is non-exponential. Consequently, it cannot be characterized by a single-time constant. Nevertheless, its time-course is completely determined by the properties of the activation and inactivation kinetics at the membrane potential at which the deinactivation of the current takes place. Moreover, we show that the recovery asymptotically approaches an exponential time-course whose time-constant, in turn, is found to be identical to that of the inactivation at the membrane potential of deinactivation. The method commonly used to reconstruct the recovery process can, therefore, provide a way of estimating the inactivation time-constant at membrane potentials where a measurement with the usual voltage-clamp protocol would not be possible. The conclusions of our analysis are discussed with regard to recent theoretical and experimental results.
在本文中，我们对电压依赖性电导服从霍奇金-赫胥黎方程的失活电流恢复过程进行了理论分析。我们证明恢复过程是复杂的，特别是非指数形式的。因此，它不能用单一的时间常数来表征。然而，其时间进程完全由电流去失活时膜电位处的激活和失活动力学特性所决定。此外，我们表明恢复渐近地趋近于一个指数时间进程，其时间常数又被发现与去失活膜电位处的失活时间常数相同。因此，通常用于重建恢复过程的方法可以提供一种在使用常规电压钳制方案无法进行测量的膜电位处估计失活时间常数的方法。我们根据最近的理论和实验结果对分析结论进行了讨论。
