Miller R H
Dept. of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
Trends Neurosci. 1996 Mar;19(3):92-6. doi: 10.1016/s0166-2236(96)80036-1.
In the adult vertebrate CNS, oligodendrocytes are ubiquitously distributed throughout white matter. By contrast, in the embryonic CNS, recent studies suggest that oligodendrocyte precursors arise in a discrete ventral location. Thus, local ventral environmental signals that contribute to the overall patterning of the CNS are likely to influence the initial appearance of oligodendrocyte precursors. Oligodendrocyte precursors subsequently disperse through the CNS by mechanisms that remain elusive. While the program to differentiate to oligodendrocytes appears to be cell autonomous, the local environment may regulate the precise temporal and spatial patterning of myelination.
在成年脊椎动物的中枢神经系统中，少突胶质细胞普遍分布于整个白质。相比之下，在胚胎中枢神经系统中，最近的研究表明少突胶质细胞前体起源于一个离散的腹侧位置。因此，有助于中枢神经系统整体模式形成的局部腹侧环境信号可能会影响少突胶质细胞前体的最初出现。少突胶质细胞前体随后通过仍不清楚的机制在中枢神经系统中扩散。虽然分化为少突胶质细胞的程序似乎是细胞自主的，但局部环境可能会调节髓鞘形成的精确时空模式。
