Gerfen C R, Clavier R M
Brain Res Bull. 1979 May-Jun;4(3):347-53. doi: 10.1016/s0361-9230(79)80012-x.
The prefrontal cortex, dorsal to the rhinal sulcus of the rat (hereinafter termed the agranular insular cortex) has been examined with the use of the retrograde transport of horseradish peroxidase. Labelled perikarya were seen in the region of the ipsilateral medial forebrain bundle, consistently rostral to the caudal edge of the posterior mammillary nucleus. These cells were interpreted as being the rostral members of the A10 dopaminergic cell group. Labelled cells were also seen in the dorsal raphe nucleus, the ipsilateral pyriform cortex, the contralateral agranular insular cortex, the ipsilateral basolateral amygdaloid nucleus, the ipsilateral locus coeruleus, and the medio-dorsal, ventromedial, and parafascicular thalamic nuclei. Detailed examination of the thalamic input confirmed a differential innervation of the dorsal and ventral regions of the agranular insular cortex. Possible functional correlates of these prefrontal afferents are discussed.
利用辣根过氧化物酶的逆行运输法，对大鼠鼻沟背侧的前额叶皮质（以下称为无颗粒岛叶皮质）进行了研究。在同侧内侧前脑束区域可见标记的神经元胞体，始终位于乳头体后核尾缘的前方。这些细胞被解释为A10多巴胺能细胞群的前部成员。在中缝背核、同侧梨状皮质、对侧无颗粒岛叶皮质、同侧基底外侧杏仁核、同侧蓝斑以及丘脑的内侧背核、腹内侧核和束旁核中也可见标记细胞。对丘脑输入的详细检查证实了无颗粒岛叶皮质背侧和腹侧区域的不同神经支配。讨论了这些前额叶传入神经可能的功能相关性。
