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一项正电子发射断层扫描(PET)研究中对老年正常受试者边缘系统回路的情绪激活。

Emotional activation of limbic circuitry in elderly normal subjects in a PET study.

作者信息

Paradiso S, Robinson R G, Andreasen N C, Downhill J E, Davidson R J, Kirchner P T, Watkins G L, Ponto L L, Hichwa R D

机构信息

University of Iowa Hospitals and Clinics, Department of Psychiatry Administration, Iowa City 52242, USA.

出版信息

Am J Psychiatry. 1997 Mar;154(3):384-9. doi: 10.1176/ajp.154.3.384.

Abstract

OBJECTIVE

This study was undertaken to identify brain structures associated with emotion in normal elderly subjects.

METHOD

Eight normal subjects aged 55-78 years were shown film clips intended to provoke the emotions of happiness, fear, or disgust as well as a neutral state. During emotional activation, regional cerebral blood flow was measured with the use of [15O]H2O positron emission tomography imaging, and subjective emotional responses were recorded. Data were analyzed by subtracting the values during the neutral condition from the values in the various emotional activations.

RESULTS

The stimuli produced a general activation in visual pathways that included the primary and secondary visual cortex, involving regions associated with object and spatial recognition. In addition, the specific emotions produced different regional limbic activations, which suggests that different pathways may be used for different types of emotional stimuli.

CONCLUSIONS

Emotional activation in normal elderly subjects was associated with increases in blood flow in limbic and paralimbic brain structures. Brain activation may be specific to the emotion being elicited but probably involves complex sensory, association, and memory circuitry. Further studies are needed to identify activations that are specific for emotion.

摘要

目的

本研究旨在确定正常老年受试者中与情绪相关的脑结构。

方法

向8名年龄在55 - 78岁的正常受试者展示旨在引发快乐、恐惧或厌恶情绪以及中性状态的电影片段。在情绪激活期间,使用[15O]H2O正电子发射断层扫描成像测量局部脑血流,并记录主观情绪反应。通过从各种情绪激活时的值中减去中性状态时的值来分析数据。

结果

刺激在视觉通路中产生了广泛激活,包括初级和次级视觉皮层,涉及与物体和空间识别相关的区域。此外,特定情绪产生了不同的边缘系统区域激活,这表明不同类型的情绪刺激可能使用不同的通路。

结论

正常老年受试者的情绪激活与边缘和边缘旁脑结构中的血流增加有关。脑激活可能特定于所引发的情绪,但可能涉及复杂的感觉、联合和记忆回路。需要进一步研究以确定特定于情绪的激活。

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