Tho K S, Krishnamoorthy S
Department of Orthopaedic Surgery, Alexandra Hospital, Singapore.
Ann Acad Med Singap. 1996 Nov;25(6):824-7.
The search for suitable bone graft substitutes has been made necessary by the problems encountered when using autogenous sources. Coral grafts have been used for the past two decades in various fields of surgery with reported good results. The aim of this study was to determine the efficacy of coral graft (Biocoral in anterior interbody fusion of rabbit spine. Fourteen rabbits underwent surgical anterior interbody fusion with autogenous, coral and Kiel grafts. At three months there was evidence of new bone formation at the graft-bone interface but no signs of osteointegration of the coral graft. The coral graft was also inert and did not evoke in any inflammatory reactions. Radiological examinations did not reveal any signs of fusion at three months. Kiel grafts only evoked a fibrous reaction. Autogenous rib grafts used has solid interbody fusion at two months as evidenced from both radiological and histological studies.
由于使用自体骨源时遇到的问题，寻找合适的骨移植替代物成为必要。在过去二十年中，珊瑚移植已在各种外科领域中使用，据报道效果良好。本研究的目的是确定珊瑚移植（Biocoral）在兔脊柱前路椎间融合中的疗效。十四只兔子接受了自体骨、珊瑚和Kiel移植的前路椎间融合手术。三个月时，在移植骨界面有新骨形成的证据，但没有珊瑚移植骨整合的迹象。珊瑚移植也是惰性的，没有引发任何炎症反应。放射学检查在三个月时未显示融合的任何迹象。Kiel移植仅引发纤维反应。从放射学和组织学研究来看，使用的自体肋骨移植在两个月时实现了坚实的椎间融合。
