烟曲霉从 Reichstein's 物质 S 形成的新型还原和羟基化产物。

Novel reduction and hydroxylation products formed by Aspergillus fumigatus from Reichstein's substance S.

作者信息

Garai S, Mahato S B

机构信息

Indian Institute of Chemical Biology, Calcutta, India.

出版信息

Steroids. 1997 Feb;62(2):253-7. doi: 10.1016/s0039-128x(96)00205-x.

DOI:10.1016/s0039-128x(96)00205-x

PMID:9055385

Abstract

Fermentation of Reichstein's Substance S with Aspergillus fumigatus (AM-21) under aerobic conditions yielded 17 alpha, 21-dihydroxy-5 alpha-pregn-l-ene-3.20-dione. 17 alpha,20 alpha, 21-trihydroxy-5 alpha-pregn-l-en-3-one. 6 beta,17 alpha, 21-trihydroxypregn-4-en-3,20-dione. 15 beta,17 alpha,21-trihydroxy-5 alpha-pregnane-3,20-dione, and 15 beta, 17 alpha,20 alpha,21-tetrahydroxy-5 alpha-pregn-l-en-3-one. Each microbial metabolite was characterized by spectroscopic methods, including 13C NMR chemical shifts.

摘要

在需氧条件下，用烟曲霉（AM - 21）对 Reichstein's 物质 S 进行发酵，产生了 17α,21 - 二羟基 - 5α - 孕 - 1 - 烯 - 3,20 - 二酮、17α,20α,21 - 三羟基 - 5α - 孕 - 1 - 烯 - 3 - 酮、6β,17α,21 - 三羟基孕 - 4 - 烯 - 3,20 - 二酮、15β,17α,21 - 三羟基 - 5α - 孕烷 - 3,20 - 二酮以及 15β,17α,20α,21 - 四羟基 - 5α - 孕 - 1 - 烯 - 3 - 酮。每种微生物代谢产物均通过光谱方法进行了表征，包括 13C NMR 化学位移。