Vijaykumar D K, Kanan R R, Chaturvedi H K
Shirdi Sai Baba Cancer Hospital & Research Centre, Kasturba Medical College, Manipal, India.
Indian J Cancer. 1996 Sep;33(3):122-9.
This is a retrospective analysis of all plantar acral melanomas treated at the Cancer Institute (WIA) Madras between January 1981 and December 1990. Acral melanomas constitute 26% of all melanomas in this population, the sole of the foot being the dominant site (35 of 36 cases). We have found that it is more common in the lower socioeconomic strata, occurs often over weight bearing areas and is usually advanced at presentation. The projected five year survival was 51% while the five year disease free survival was only 22%. Pathological nodal status was found to be the only factor significantly influencing survival in this study. Wide local excision was found to give results equivalent to radical amputation and is strongly recommended since it gives a much better quality of life with a disease that has an overall dismal prognosis.
这是一项对1981年1月至1990年12月期间在马德拉斯癌症研究所（WIA）接受治疗的所有足底肢端黑色素瘤的回顾性分析。肢端黑色素瘤占该人群所有黑色素瘤的26%，其中足底是主要发病部位（36例中的35例）。我们发现，它在社会经济地位较低的阶层中更为常见，常发生在负重区域，且就诊时通常已处于晚期。预计五年生存率为51%，而五年无病生存率仅为22%。在本研究中，病理淋巴结状态被发现是唯一显著影响生存的因素。广泛局部切除的结果与根治性截肢相当，强烈推荐采用广泛局部切除，因为对于这种总体预后不佳的疾病，它能带来更好的生活质量。
