Hore S K, Dumka V K, Kumar D, Tripathi H C, Tandan S K
Division of Pharmacology & Toxicology, Indian Veterinary Research Institute, Izatnagar.
Indian J Med Res. 1997 Feb;105:93-7.
The possibility of central noradrenergic and dopaminergic modulation of Brewer's yeast-induced peripheral inflammation was investigated in rats. Centrally administered noradrenaline (NA), amphetamine, which liberates NA and dopamine in the central nervous system and L-dopa, the precursor of dopamine significantly suppressed paw oedema. Conversely, the beta-adrenoceptor blocker, propranolol, catecholaminergic neuron degenerator, 6-hydroxydopamine (6-OHDA), dopaminergic antagonist, haloperidol and dopamine synthesis inhibitor, alpha-methyl para tyrosine (AMPT) augmented paw oedema. In addition, 6-OHDA and haloperidol produced significant reduction in pain threshold. The results of this study indicate that central NA and dopamine exert inhibitory effects on Brewer's yeast-induced peripheral inflammation.
在大鼠中研究了中枢去甲肾上腺素能和多巴胺能对啤酒酵母诱导的外周炎症的调节作用。中枢给予去甲肾上腺素（NA）、能在中枢神经系统释放NA和多巴胺的苯丙胺以及多巴胺的前体左旋多巴，可显著抑制爪部水肿。相反，β-肾上腺素能受体阻滞剂普萘洛尔、儿茶酚胺能神经元变性剂6-羟基多巴胺（6-OHDA）、多巴胺能拮抗剂氟哌啶醇和多巴胺合成抑制剂α-甲基对酪氨酸（AMPT）可加重爪部水肿。此外，6-OHDA和氟哌啶醇可使痛阈显著降低。本研究结果表明，中枢NA和多巴胺对啤酒酵母诱导的外周炎症具有抑制作用。
