α-干扰素2b治疗乙肝携带者。对感染不同基因型的儿童乙肝病毒DNA水平的影响。

Interferon-alpha 2b treatment in hepatitis B carriers. Effect on hepatitis B virus DNA levels in children infected with different genotypes.

作者信息

Sangfelt P, Norder H, Magnius L O, Alaeus A, Carlsson T, Reichard O

机构信息

Department of Medicine, University Hospital, Uppsala, Sweden.

出版信息

Acta Paediatr. 1997 Feb;86(2):135-7. doi: 10.1111/j.1651-2227.1997.tb08853.x.

DOI:10.1111/j.1651-2227.1997.tb08853.x

PMID:9055880

Abstract

Eleven hepatitis B virus (HBV) carrier children, infected with genotypes A-D, were treated with interferon-alpha. Two children had a sustained loss of hepatitis B e-antigen and HBV DNA. They were infected with the non-Asian genotypes A and D, and had low HBV DNA and high ALT levels in serum before treatment. However, HBV DNA titres decreased during treatment also in children infected with the East-Asian genotypes B and C.

摘要

11名感染了A - D基因型的乙型肝炎病毒（HBV）携带者儿童接受了α干扰素治疗。两名儿童出现乙型肝炎e抗原和HBV DNA持续消失。他们感染的是非亚洲基因型A和D，治疗前血清中HBV DNA水平低且ALT水平高。然而，感染东亚基因型B和C的儿童在治疗期间HBV DNA滴度也有所下降。