帕特利辛A新衍生物在小鼠脑隐球菌病模型中的强效抗真菌作用。
Potent antifungal effects of a new derivative of partricin A in a murine model of cerebral cryptococcosis.
作者信息
Luna T, Mazzolla R, Romanò G, Blasi E
机构信息
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.
出版信息
Antimicrob Agents Chemother. 1997 Mar;41(3):706-8. doi: 10.1128/AAC.41.3.706.
Abstract
A new member of the polyene family, N-dimethylaminoacetyl-partricin A 2-dimethylaminoethylamide diaspartate (SPA), was investigated and was found to be more effective than amphotericin B (i) in vivo by enhancing mouse resistance to cryptococcal meningoencephalitis and (ii) in vitro by potentiating the anticryptococcal activity of murine microglial cells.
摘要
对多烯家族的一个新成员N-二甲基氨基乙酰-派洛星A 2-二甲基氨基乙酰胺天冬氨酸二盐（SPA）进行了研究，发现其在体内通过增强小鼠对隐球菌性脑膜脑炎的抵抗力，以及在体外通过增强小鼠小胶质细胞的抗隐球菌活性，比两性霉素B更有效。
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