Kozel T R, Pfrommer G S, Guerlain A S, Highison B A, Highison G J
Department of Microbiology, School of Medicine, University of Nevada School of Medicine, Reno 89557.
Rev Infect Dis. 1988 Jul-Aug;10 Suppl 2:S436-9. doi: 10.1093/cid/10.supplement_2.s436.
The capsule is closely associated with the virulence of Cryptococcus neoformans. The capsule inhibits phagocytosis by macrophages, monocytes, and neutrophils. Studies in our laboratory have shown that incubation of encapsulated cryptococci in normal human serum leads to deposition of large amounts of C3 fragments at the surface of the yeast and lesser amounts of IgG within the capsule. Thus, the capsule mediates two biologic activities with opposing effects. It is our current view that phagocytosis of the yeast is dependent on a balance between the antiphagocytic action of cryptococcal polysaccharide and the ability of the yeast to focus opsonically active complement fragments and the IgG at the capsular surface.
荚膜与新型隐球菌的毒力密切相关。荚膜可抑制巨噬细胞、单核细胞和中性粒细胞的吞噬作用。我们实验室的研究表明，将有荚膜的隐球菌置于正常人血清中孵育，会导致大量C3片段沉积在酵母表面，而荚膜内有少量IgG沉积。因此，荚膜介导了两种具有相反作用的生物学活性。我们目前的观点是，酵母的吞噬作用取决于隐球菌多糖的抗吞噬作用与酵母将具有调理活性的补体片段和IgG聚集在荚膜表面的能力之间的平衡。
