Yu C P, Ding Y J, Zhang L, Oberdörster G, Mast R W, Maxim L D, Utell M J
State University of New York at Buffalo, Amherst 14260, USA.
Regul Toxicol Pharmacol. 1997 Feb;25(1):18-25. doi: 10.1006/rtph.1996.1064.
A mathematical retention model has been developed to predict the lung burden and size distribution of kaolin refractory ceramic fibers (RCF) in the pulmonary region of the human lung during exposure. Fiber dissolution, breakage, and differential clearance are considered in this model; rates for these processes are obtained by extrapolation from available data on laboratory rats. The lung burden predicted by this model is in general agreement with fiber counts from three factory workers. An important prediction from this study is that clearance of RCF is not significantly impaired at a fiber concentration beneath 10 f/cm3 during occupational exposure.
已开发出一种数学滞留模型，以预测人体肺部在暴露期间高岭土耐火陶瓷纤维（RCF）在肺部区域的肺负荷和尺寸分布。该模型考虑了纤维溶解、断裂和差异清除；这些过程的速率通过从实验室大鼠的现有数据外推获得。该模型预测的肺负荷与三名工厂工人的纤维计数总体一致。这项研究的一个重要预测是，在职业暴露期间，纤维浓度低于10 f/cm3时，RCF的清除不会受到显著损害。
