骨髓瘤患者家族中的免疫球蛋白
Immunoglobulins in families of myeloma patients.
作者信息
Festen J J, Marrink J, de Waard-Kuiper E H, Mandema E
出版信息
Scand J Immunol. 1977;6(9):887-96. doi: 10.1111/j.1365-3083.1977.tb00409.x.
The serum immunoglobulin levels of 200 first-degree relatives and 23 spouses of 32 patients with myelomatosis were compared with those of age- and sex-matched control persons. First-degree relatives of myeloma patients appeared to have higher serum levels of IgG (P less than 0.05), IgA (P less than 0.05), and IgM (P less than 0.01) than their age- and sex-matched controls. The spouses as a group did not differ from their controls in this respect. No statistically significant difference in the incidence of M-components among family members (0.6%) and spouses (4.3%) was found compared with the incidence in the general population (0.9%). Myelomatosis as such appeared to be more frequent than in the general population (P less than 0.05).
将32例骨髓瘤病患者的200名一级亲属和23名配偶的血清免疫球蛋白水平与年龄和性别匹配的对照者进行了比较。骨髓瘤患者的一级亲属的血清IgG（P<0.05）、IgA（P<0.05）和IgM（P<0.01）水平似乎高于其年龄和性别匹配的对照者。在这方面，配偶组与对照组没有差异。与普通人群（0.9%）的发病率相比，家庭成员（0.6%）和配偶（4.3%）中M成分的发病率没有统计学上的显著差异。骨髓瘤病本身似乎比普通人群更常见（P<0.05）。
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