伴有家族性淀粉样多发性神经病关节淀粉样沉积的夏科氏膝关节病

Charcot knee arthropathy with articular amyloid deposition in familial amyloidotic polyneuropathy.

作者信息

Shiraishi M, Ando Y, Mizuta H, Nakamura E, Takagi K, Ando M

机构信息

Department of Orthopaedic Surgery, Kumamoto University School of Medicine, Japan.

出版信息

Scand J Rheumatol. 1997;26(1):61-4. doi: 10.3109/03009749709065667.

DOI:10.3109/03009749709065667

PMID:9057805

Abstract

An extremely rare case of familial amyloidotic polyneuropathy (FAP) complicated by neuroarthropathy (Charcot joint) in the left knee joint and by intra-articular deposits of amyloid was observed. FAP-specific variant transthyretin (TTR) was found in the synovial fluid and amyloid deposits were confirmed in the synovium, cartilage and bone by Congo red staining and immuno-staining.

摘要

观察到一例极为罕见的家族性淀粉样多神经病（FAP），其并发左膝关节神经关节病（夏科关节）及关节内淀粉样沉积物。在滑液中发现了FAP特异性变异转甲状腺素蛋白（TTR），并通过刚果红染色和免疫染色在滑膜、软骨和骨中证实了淀粉样沉积物。