c-erbB-2表达可预测临床胃癌的淋巴转移。
c-erbB-2 expression is predictive for lymphatic spread of clinical gastric carcinoma.
作者信息
Orita H, Maehara Y, Emi Y, Kakeji Y, Baba H, Korenaga D, Sugimachi K
机构信息
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Hepatogastroenterology. 1997 Jan-Feb;44(13):294-8.
BACKGROUND/AIMS: In patients with gastric carcinoma, the prognostic significance of c-erbB-2 oncogene expression was elucidated, but its role in the aggressive behavior of tumors is not clear.
PATIENTS AND METHODS
We asked whether or not cerbB-2 gene expression may have predictability with regard to the metastatic potential in 160 patients with gastric carcinoma using a immunohistochemical staining and a multivariate analysis.
RESULTS
c-erbB-2 immunoreactivity was observed in 11% (17/160) of tumors. Patients with c-erbB-2 product positive tumors had a significant shorter prognosis (p < 0.05), and were characterized by a high incidence of peritoneal dissemination (41%), liver metastasis (18%) and lymph node involvement (94%). In the multivariate logistic analysis revealed that c-erbB-2 expression was a significant risk factor related to lymph node involvement (p < 0.01).
CONCLUSIONS
Our multivariate analysis revealed that c-erbB-2 expression is linked to the metastatic potential in patients with gastric carcinoma.
背景/目的：在胃癌患者中，已阐明c-erbB-2癌基因表达的预后意义，但其在肿瘤侵袭行为中的作用尚不清楚。
患者与方法
我们采用免疫组织化学染色和多因素分析，探讨160例胃癌患者中cerbB-2基因表达对转移潜能是否具有预测性。
结果
11%（17/160）的肿瘤中观察到c-erbB-2免疫反应性。c-erbB-2产物阳性肿瘤患者的预后明显较短（p<0.05），其特征为腹膜播散发生率高（41%）、肝转移（18%）和淋巴结受累（94%）。多因素逻辑分析显示，c-erbB-2表达是与淋巴结受累相关的显著危险因素（p<0.01）。
结论
我们的多因素分析显示，c-erbB-2表达与胃癌患者的转移潜能有关。
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