Helvacioglu A, Aksel S, Peterson R D
Gynecology and Infertility Associates, Point Clear, Alabama 36564, USA.
J Reprod Med. 1997 Feb;42(2):71-5.
To determine whether the decreased mitogenicity of the endometrial cell for autologous lymphocytes noted in women with pelvic endometriosis is secondary to endometrial cell interaction with the lymphocytes or due to an inherent defect of the lymphocyte.
The endometrial cells from 30 women with endometriosis and 30 matching controls were cultured. Autologous lymphocyte and endometrial cells were cocultured to observe the lymphocyte proliferative response to autologous endometrium in controls and to ectopic and eutopic endometrial cells from patients. The ability of lymphocytes to be stimulated by phytohemagglutinin (PHA) was simultaneously assayed.
Ectopic and eutopic endometrial cells from women with endometriosis were less mitogenic for autologous lymphocytes than endometrial cells from controls. The lymphocytes from both patients and controls exhibited a similar stimulatory response to PHA.
The diminished proliferative response of lymphocytes from women with endometriosis probably is not the consequence of an intrinsic lymphocyte abnormality. The fundamental defect in endometriosis may reside within the endometrial cell.
确定盆腔子宫内膜异位症女性中所观察到的子宫内膜细胞对自身淋巴细胞促有丝分裂活性降低是子宫内膜细胞与淋巴细胞相互作用的结果，还是淋巴细胞固有缺陷所致。
培养30例子宫内膜异位症女性及30例匹配对照的子宫内膜细胞。将自身淋巴细胞与子宫内膜细胞共培养，以观察对照组中淋巴细胞对自身子宫内膜以及患者异位和在位子宫内膜细胞的增殖反应。同时检测淋巴细胞对植物血凝素（PHA）的反应能力。
子宫内膜异位症女性的异位和在位子宫内膜细胞对自身淋巴细胞的促有丝分裂活性低于对照组的子宫内膜细胞。患者和对照组的淋巴细胞对PHA均表现出相似的刺激反应。
子宫内膜异位症女性淋巴细胞增殖反应减弱可能并非淋巴细胞内在异常所致。子宫内膜异位症的根本缺陷可能存在于子宫内膜细胞内。
