癌症初发儿童的视黄醇（维生素A）和视网膜结合蛋白血清水平。

Retinol (vitamin A) and retinal-binding protein serum levels in children with cancer at onset.

作者信息

Fiore P, Castagnola E, Marchese N, Dufour C, Garaventa A, Mangraviti S, Cornaglia-Ferraris P

机构信息

Department of Dietetics, Giannina Gaslini Institute, Genova, Italy.

出版信息

Nutrition. 1997 Jan;13(1):17-20. doi: 10.1016/s0899-9007(97)90873-x.

DOI:10.1016/s0899-9007(97)90873-x

PMID:9058442

Abstract

The aim of the study was to evaluate vitamin A (Vit A) plasma levels in children with newly diagnosed neoplasia (NDN) admitted to the Department of Hematology-Oncology of G. Gaslini Institute. Vit A levels, retinol-binding protein (RBP), and nutritional status were evaluated in 54 children with NDN (22 solid tumors other than neuroblastoma, 16 neuroblastomas, 9 lymphomas, 7 acute lymphoblastic leukemia). Biochemical test results were also compared with those of 47 healthy controls (HC) comparable for sex and age. In children with NDN, mean Vit A plasma level results were 350 micrograms/L (95% CI 288-412); in HC they were 517 micrograms/L (95% CI 471-563), P < 0.001. Mean RBP value results were 3.2 mg/dL (95% CI 2.6-3.9) in NDN and 4.9 mg/dL in HC (95% CI 4.5-5.3), P < 0.001. Fifteen (28%) out of 54 children with NDN were classified as well-nourished, 27/54 (50%) were considered at risk of malnutrition, and 12 (22%) were malnourished. Children with NDN presented reduced Vit A and RBP mean values compared with those of HC. Further studies are needed to better evaluate Vit A metabolism in children with cancer at onset.

摘要

本研究的目的是评估入住G. Gaslini研究所血液肿瘤学系的新诊断肿瘤患儿（NDN）的血浆维生素A（Vit A）水平。对54例NDN患儿（22例非神经母细胞瘤实体瘤、16例神经母细胞瘤、9例淋巴瘤、7例急性淋巴细胞白血病）的Vit A水平、视黄醇结合蛋白（RBP）和营养状况进行了评估。还将生化检测结果与47例年龄和性别匹配的健康对照（HC）的结果进行了比较。在NDN患儿中，血浆Vit A平均水平为350微克/升（95%可信区间288 - 412）；在HC中为517微克/升（95%可信区间471 - 563），P < 0.001。NDN患儿的RBP平均水平为3.2毫克/分升（95%可信区间2.6 - 3.9），HC为4.9毫克/分升（95%可信区间4.5 - 5.3），P < 0.001。54例NDN患儿中有15例（28%）被归类为营养良好，27/54（50%）被认为有营养不良风险，12例（22%）营养不良。与HC相比，NDN患儿的Vit A和RBP平均水平降低。需要进一步研究以更好地评估癌症患儿发病时的Vit A代谢情况。