Walcott G P, Knisley S B, Zhou X, Newton J C, Ideker R E
Department of Medicine, University of Alabama at Birmingham 35294, USA.
Pacing Clin Electrophysiol. 1997 Feb;20(2 Pt 2):422-31. doi: 10.1111/j.1540-8159.1997.tb06201.x.
The mechanism of ventricular defibrillation can be considered at many different levels. The highest level is considered at strength of the shock given through the defibrillation electrodes. At the next level, the mechanism of defibrillation can be examined in terms of the electrical field that the shock produces throughout the ventricles. Other levels include the effects this electric field has on the activation sequences and on the cellular action potentials that either initiate or inhibit the early sites of activation following the shock. Yet another level considers the mechanism by which the shock field initiates new action potentials or prolongs the action potential by changing the transmembrane potential during the shock. Finally, the subcellular level is considered, which involves the response of the individual ion channels to the shock. This review gives a brief overview of some salient features of defibrillation at each of these mechanistic levels.
心室除颤机制可在许多不同层面进行探讨。最高层面是考虑通过除颤电极施加的电击强度。下一个层面，可从电击在整个心室内产生的电场角度来研究除颤机制。其他层面包括该电场对激活序列以及对电击后引发或抑制早期激活位点的细胞动作电位的影响。还有一个层面考虑电击场通过在电击期间改变跨膜电位来引发新动作电位或延长动作电位的机制。最后是亚细胞层面，涉及单个离子通道对电击的反应。本综述简要概述了这些机制层面中每个层面除颤的一些显著特征。
