Nagaoka S, Awano T, Nagata N, Masaoka M, Hori G, Hashimoto K
Department of Food Science, Faculty of Agriculture, Gifu University, Japan.
Biosci Biotechnol Biochem. 1997 Feb;61(2):354-6. doi: 10.1271/bbb.61.354.
The serum cholesterol level in rats was significantly decreased in a group fed on a soyprotein peptic hydrolyzate (SPH) when compared with a group fed on a casein tryptic hydrolyzate (CTH). The fecal excretion of total steroids was significantly greater with rats fed on the SPH diet when compared with the CTH diet. The results of CaCo-2 studies clearly suggest that the suppression of cholesterol absorption in the intestinal epithelia is part of the mechanism for the hypocholesterolemic action induced by SPH.
与喂食酪蛋白胰蛋白酶水解物（CTH）的大鼠组相比，喂食大豆蛋白胃蛋白酶水解物（SPH）的大鼠组血清胆固醇水平显著降低。与CTH饮食组相比，喂食SPH饮食的大鼠粪便中总类固醇的排泄量显著增加。CaCo-2研究结果清楚地表明，抑制肠道上皮细胞中的胆固醇吸收是SPH诱导降胆固醇作用机制的一部分。
