Remadi S, Lifschitz-Mercer B, Ben-Hur H, Dgani R, Czernobilsky B
Institut de Pathologie Clinique, Hôpital Cantonal Universitaire de Genève, Switzerland.
Arch Gynecol Obstet. 1997;259(2):97-103. doi: 10.1007/BF02505316.
Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.
胎盘部位滋养细胞肿瘤（PSTT）是妊娠滋养细胞肿瘤的一种罕见形式。PSTT的临床行为通常为良性，但有时可能具有高度恶性，出现晚期复发和转移。我们分别描述了两例年龄为35岁和29岁的伴有肺转移的PSTT病例。有丝分裂率分别升高至每10个高倍视野9个和13个有丝分裂象。免疫组织化学染色显示，其中1例人胎盘催乳素（hPL）阳性细胞占优势，而人绒毛膜促性腺激素（hCG）反应性细胞较少；另一例则呈现相反模式。1例的DNA检测显示为非整倍体肿瘤，有一个四倍体DNA峰。PSTT的临床行为仍然难以预测，并且没有可靠的方法来预测临床结果。
