Johnson S P, Sebire N J, Snijders R J, Tunkel S, Nicolaides K H
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK.
Ultrasound Obstet Gynecol. 1997 Jan;9(1):14-6. doi: 10.1046/j.1469-0705.1997.09010014.x.
In an ongoing study involving seven hospitals in London and surrounding areas, 55,237 fetuses were examined by ultrasound at 10-14 weeks of gestation. There were 47 fetuses (1 in 1175) with anencephaly which presented with acrania with varying degrees of cerebral degeneration. The first audit of results was performed in April 1995. During the first phase of the study 34,830 fetuses were examined and in eight of the 31 with anencephaly the diagnosis was not made at the 10-14-week scan. Following the audit, 20,407 fetuses were examined and in all 16 with anencephaly the diagnosis was made at the 10-14-week scan (p = 0.03). These findings demonstrate that anencephaly can be reliably diagnosed at the routine 10-14-week ultrasound scan, provided a specific search is made for the sonographic features for this condition.
在一项正在进行的涉及伦敦及周边地区七家医院的研究中，对55237例妊娠10 - 14周的胎儿进行了超声检查。有47例（1/1175）无脑儿，表现为无颅骨并伴有不同程度的脑退变。1995年4月进行了首次结果审核。在研究的第一阶段，检查了34830例胎儿，在31例无脑儿中有8例在10 - 14周扫描时未作出诊断。审核后，检查了20407例胎儿，所有16例无脑儿在10 - 14周扫描时均作出了诊断（p = 0.03）。这些发现表明，只要针对这种情况的超声特征进行专门检查，无脑儿在常规的10 - 14周超声扫描时就能得到可靠诊断。
