Beinder E, Grüner C, Erhardt I, Mauch E, Begon S
Universitäts-Frauenklinik Erlangen.
Ultraschall Med. 1995 Aug;16(4):192-5. doi: 10.1055/s-2007-1003937.
In animal studies exencephaly is well described as a precursor of anencephaly. We have evidence that also in the human fetus the transition from exencephaly to anencephaly is possible.
We diagnosed either exencephaly or anencephaly by high-frequency vaginal ultrasound in 14 human fetuses at gestational ages varying between 9 + 4 and 22 + 3 weeks.
In the first trimester exencephaly was the predominant finding, while in the second trimester the classic appearance of anencephaly was seen more often. In one fetus with exencephaly diagnosed at a gestational age of 12 + 2 weeks, where the parents decided not to intervene, the transition to anencephaly was documented by serial ultrasound examinations.
Our findings support an exencephaly-anencephaly sequence also in humans. The cephalic changes resulting in the classic anencephalic appearance are of importance for the first trimester diagnosis with high resolution vaginal probe ultrasound.
在动物研究中，无脑前畸形被充分描述为无脑儿的先兆。我们有证据表明，在人类胎儿中，从无脑前畸形转变为无脑儿也是可能的。
我们通过高频阴道超声对14例孕龄在9 + 4至22 + 3周之间的人类胎儿诊断出无脑前畸形或无脑儿。
在孕早期，无脑前畸形是主要发现，而在孕中期，无脑儿的典型表现更为常见。在1例孕12 + 2周时诊断为无脑前畸形的胎儿中，其父母决定不干预，通过系列超声检查记录到了向无脑儿的转变。
我们的研究结果支持人类中也存在无脑前畸形 - 无脑儿序列。导致典型无脑儿外观的头部变化对于使用高分辨率阴道探头超声进行孕早期诊断很重要。
