Ganguly P K, Dhalla K S, Shao Q, Beamish R E, Dhalla N S
Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada.
Am Heart J. 1997 Mar;133(3):340-5. doi: 10.1016/s0002-8703(97)70230-8.
Although congestive heart failure subsequent to myocardial infarction is known to be associated with increased sympathetic activity, very little information regarding changes in the sympathetic nerves in the left and right ventricles at various stages after infarction is available. Male Sprague-Dawley rats were subjected to coronary artery ligation and studied 4 and 8 weeks later; these animals had mild and moderate stages of congestive heart failure. A sham group, without coronary ligation, was used as control. Four weeks after myocardial infarction, plasma and ventricular (left and right) epinephrine (EPI), unlike norepinephrine (NE), were markedly increased. Whereas plasma catecholamine (EPI and NE) levels were increased 8 weeks after infarction, NE concentration in the left ventricle was unchanged but EPI concentration was increased in comparison with sham control. The right ventricle showed an increased level of both NE and EPI 8 weeks after infarction. Measurement of the rate of change in the specific activity of NE (NE turnover) in the left and right ventricles 8 weeks after infarction revealed an increase in NE turnover in the left ventricle, without any changes in the right ventricle. The concentration of EPI, unlike NE, was increased in the kidney, spleen, and brain 8 weeks after coronary occlusion. These results are interpreted to mean that congestive heart failure caused by myocardial infarction is associated with differential changes in the status of sympathetic nerves in the left and right ventricles; sympathetic activity is increased only in the left ventricle, whereas the right ventricle may play an adaptive role by increasing catecholamine stores during the development of heart failure.
尽管已知心肌梗死后的充血性心力衰竭与交感神经活动增加有关，但关于梗死后不同阶段左、右心室交感神经变化的信息却非常少。将雄性斯普拉格-道利大鼠进行冠状动脉结扎，并在4周和8周后进行研究；这些动物处于充血性心力衰竭的轻度和中度阶段。将未进行冠状动脉结扎的假手术组作为对照。心肌梗死后4周，血浆和心室（左、右）肾上腺素（EPI）与去甲肾上腺素（NE）不同，显著增加。虽然梗死后8周血浆儿茶酚胺（EPI和NE）水平升高，但左心室NE浓度未变，而与假手术对照相比，EPI浓度升高。梗死后8周，右心室NE和EPI水平均升高。对梗死后8周左、右心室NE比活性变化率（NE周转率）的测量显示，左心室NE周转率增加，而右心室无变化。冠状动脉闭塞8周后，肾脏、脾脏和大脑中EPI浓度与NE不同，有所增加。这些结果被解释为意味着心肌梗死引起的充血性心力衰竭与左、右心室交感神经状态的差异变化有关；交感神经活动仅在左心室增加，而右心室可能在心力衰竭发展过程中通过增加儿茶酚胺储备发挥适应性作用。
