Giorgi F, Bascioni R, De Signoribus G, Di Saverio F
Oncology Unit, Ospedale Madonna del Soccorso, San Benedetto del Tronto, Italy.
Tumori. 1996 Nov-Dec;82(6):585-7. doi: 10.1177/030089169608200614.
Various attempts have been made to prevent 5-fluorouracil-induced stomatitis, with unsatisfactory results. Sucralfate is an aluminum hydroxide complex of sulfated sucrose commonly used in the treatment of gastroduodenal ulcers. We used the compound in a phase II study to reduce and minimize the stomatotoxicity of 5-fluorouracil chemotherapy administered in a multiple-day schedule.
Fifty-two patients entered the study, and 129 cycles of chemotherapy were evaluated. Seven patients refused sucralfate rinses for taste intolerance.
A low level of stomatotoxicity was recorded: grade 2 stomatitis was observed after 14 cycles (10.8%) and grade 3 after 3 cycles (2.3%).
Sucralfate administration could have a role in the prevention of 5-fluorouracil-induced stomatitis.
人们已经进行了各种尝试来预防5-氟尿嘧啶引起的口腔炎，但结果并不理想。硫糖铝是一种硫酸化蔗糖的氢氧化铝复合物，常用于治疗胃十二指肠溃疡。我们在一项II期研究中使用该化合物，以减轻并最小化多日疗程的5-氟尿嘧啶化疗的口腔毒性。
52名患者进入研究，共评估了129个化疗周期。7名患者因味觉不耐受拒绝使用硫糖铝漱口。
记录到较低水平的口腔毒性：14个周期（10.8%）后观察到2级口腔炎，3个周期（2.3%）后观察到3级口腔炎。
给予硫糖铝可能在预防5-氟尿嘧啶引起的口腔炎中发挥作用。
