Hofmann G O, Kirschner M H, Wagner F D, Land W, Bühren V
Berufsgenossenschaftliche Unfallklinik Murnau, Germany.
Arch Orthop Trauma Surg. 1997;116(3):125-8. doi: 10.1007/BF00426059.
In this paper we report the first successful allogeneic vascularized transplantation of a fresh and perfused human knee joint. A 17-year-old male had lost his knee in a motorvehicle accident. The graft was harvested from a multiorgan donor, perfused with 41 UW solution and transplanted within 21 h. Osteosyntheses were performed employing intramedullary nails. Immunosuppression was based mainly on two drugs: cyclosporin A and azathioprine. Five months after the operation the patient is fully mobilized, and the graft perfusion still intact. Osteotomies of the femur and tibia demonstrate callus formation and osseous consolidation.
在本文中，我们报告了首例新鲜灌注人膝关节异体血管化移植成功的病例。一名17岁男性在机动车事故中失去了膝关节。移植物取自一名多器官捐献者，用41 UW溶液灌注，并在21小时内进行移植。采用髓内钉进行骨合成。免疫抑制主要基于两种药物：环孢素A和硫唑嘌呤。术后五个月，患者已完全恢复活动，移植物灌注仍然完好。股骨和胫骨截骨显示有骨痂形成和骨愈合。
