Baier-Bitterlich G, Fuchs D, Wachter H
Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
Immunobiology. 1996;196(4):350-5. doi: 10.1016/s0171-2985(96)80057-x.
Activated cell-mediated immunity is accompanied by elevated concentrations of interferon-gamma leading to the secretion of neopterin-derivatives which are known as sensitive immune activation markers in clinical laboratory diagnosis. Recent data imply a potential role of neopterin-derivatives in oxygen-free radical-mediated processes and a direct impact of 7,8-dihydroneopterin on tumor necrosis factor alpha-mediated programmed cell death. We report here that 7,8-dihydroneopterin and hydrogen peroxide upregulate the production of interferon-gamma, thereby establishing an autocrine feed-back loop. Data put emphasis on the role of neopterin-derivates within the cytokine network.
活化的细胞介导免疫伴随着干扰素-γ浓度升高，导致新蝶呤衍生物的分泌，这些衍生物在临床实验室诊断中被视为敏感的免疫激活标志物。最近的数据表明新蝶呤衍生物在氧自由基介导的过程中具有潜在作用，且7,8-二氢新蝶呤对肿瘤坏死因子α介导的程序性细胞死亡有直接影响。我们在此报告，7,8-二氢新蝶呤和过氧化氢上调干扰素-γ的产生，从而建立了一个自分泌反馈回路。数据强调了新蝶呤衍生物在细胞因子网络中的作用。
