Quarles R H
Myelin and Brain Development Section, NINDS, NIH, Bethesda, MD 20892, USA.
J Mol Neurosci. 1997 Feb;8(1):1-12. doi: 10.1007/BF02736858.
A growing number of glycoproteins have been identified and characterized in myelin and myelin-forming cells. In addition to the major P0 glycoprotein of compact PNS myelin and the myelin-associated glycoprotein (MAG) in the periaxonal membranes of myelin-forming oligodendrocytes and Schwann cells, the list now includes peripheral myelin protein-22 (PMP-22), a 170 kDa glycoprotein associated with PNS myelin and Schwann cells (P170k/SAG), Schwann cell myelin protein (SMP), myelin/oligodendrocyte glycoprotein (MOG), and oligodendrocyte-myelin glycoprotein (OMgp). Many of these glycoproteins are members of the immunoglobulin superfamily and express the adhesion-related HNK-1 carbohydrate epitope. This review summarizes recent findings concerning the structure and function of these glycoproteins of myelin sheaths with emphasis on the physiological roles of oligosaccharide moieties.
越来越多的糖蛋白已在髓鞘和形成髓鞘的细胞中被鉴定和表征。除了致密周围神经系统髓鞘的主要P0糖蛋白以及形成髓鞘的少突胶质细胞和施万细胞轴突周围膜中的髓鞘相关糖蛋白（MAG）外，现在这个列表还包括外周髓鞘蛋白-22（PMP-22），一种与周围神经系统髓鞘和施万细胞相关的170 kDa糖蛋白（P170k/SAG）、施万细胞髓鞘蛋白（SMP）、髓鞘/少突胶质细胞糖蛋白（MOG）和少突胶质细胞-髓鞘糖蛋白（OMgp）。这些糖蛋白中的许多是免疫球蛋白超家族的成员，并表达与黏附相关的HNK-1碳水化合物表位。本综述总结了关于这些髓鞘糖蛋白结构和功能的最新发现，重点是寡糖部分的生理作用。
