Martínez-Tallo E, Campo F, Delgado M, Marfíl S, Agulla E
Division of Pediatric Intensive Care and Pediatric Cardiology, Infanta Cristina University Hospital, Badajoz, Spain.
Pediatr Emerg Care. 1997 Feb;13(1):37-9. doi: 10.1097/00006565-199702000-00012.
The widespread use of central venous catheters in children has increased thrombotic complications that warrant thrombolytic therapy. We report the cases of two infants, aged four and two months, with a mobile thrombus in the right atrium treated with recombinant tissue-plasminogen-activator (rt-PA) infused by a central venous catheter. Clot dissolution was obtained in both patients in eight and 44 hours, respectively. One patient presented mild respiratory distress probably from a pulmonary microembolism that disappeared in a few days. Both had minor bleeding from venipuncture sites, but no major hemorrhage.
中心静脉导管在儿童中的广泛使用增加了血栓形成并发症的发生，而这些并发症需要进行溶栓治疗。我们报告了两例婴儿的病例，年龄分别为4个月和2个月，右心房有可移动血栓，通过中心静脉导管输注重组组织型纤溶酶原激活剂（rt-PA）进行治疗。两名患者的血栓分别在8小时和44小时溶解。一名患者出现轻度呼吸窘迫，可能是由肺微栓塞引起的，几天后消失。两人均有静脉穿刺部位轻度出血，但无大出血。
