DeLisi L E
Department of Psychiatry, SUNY, Stony Brook 11794, USA.
Schizophr Res. 1997 Feb 7;23(2):119-29. doi: 10.1016/S0920-9964(96)00079-5.
Chronic schizophrenia is characterized by change in the normal brain cortical structure, asymmetric reduction, and ventricular enlargement. The debate continues as to whether these anomalies occur early in development or represent an active progressive process continuing after the onset of psychosis. The case is made in the present manuscript for a continuing aberrant lifetime brain process. It is proposed that the underlying basis for the neuropathology of schizophrenia resides in the periodic activation of a defective gene or genes that determine the rate of cerebral growth. This process causes subtle cortical maldevelopment prenatally and through early childhood, is activated again during adolescent pruning of neurons, and again during the gradual aging process in the brain throughout adulthood. The case for a progressive active brain process in schizophrenia is thus presented.
慢性精神分裂症的特征是正常脑皮质结构改变、不对称性缩小以及脑室扩大。关于这些异常是在发育早期出现还是代表精神病发作后持续的活跃进展过程，争论仍在继续。本手稿提出了一种终生持续异常的脑过程。有人提出，精神分裂症神经病理学的潜在基础在于决定大脑生长速度的一个或多个缺陷基因的周期性激活。这个过程在产前和幼儿期导致轻微的皮质发育异常，在青少年神经元修剪期间再次被激活，并在成年期大脑的逐渐老化过程中再次被激活。因此，本文阐述了精神分裂症中存在进行性活跃脑过程的观点。
