Verdoux H, Takei N, Cassou de Saint-Mathurin R, Murray R M, Bourgeois M L
Department of Psychiatry, University Victor Segalen Bordeaux 2, Centre Carreire, France.
Schizophr Res. 1997 Feb 7;23(2):175-80. doi: 10.1016/s0920-9964(96)00096-5.
It has been suggested that winter birth in urban areas may be associated with an increased risk of schizophrenia. Data on 4139 patients with a hospital diagnosis of schizophrenia were obtained from a survey of public departments of psychiatry in metropolitan France. Place of birth was classified according to the administrative subdivision of French territory into 95 'départements'. Density of population in the decade and in the département of birth was identified using successive census data. A 20% excess (OR, 1.20; 95% CI, 1.03-1.40; p = 0.02) of winter births (January-March) was found among patients born in highly densely populated areas (> 136 inhabitants/km2) compared to those born in other areas. These results suggest that seasonal early environmental risk factor(s) linked to schizophrenia predominantly operate in urban areas.
有人提出，城市地区冬季出生可能与精神分裂症风险增加有关。从法国大都市地区精神病学公共部门的一项调查中获得了4139例医院诊断为精神分裂症患者的数据。出生地点根据法国领土的行政分区划分为95个“省”。利用连续的人口普查数据确定出生十年间及出生省份的人口密度。与其他地区出生的患者相比，在人口高度密集地区（>136人/平方公里）出生的患者中，冬季出生（1月至3月）的比例高出20%（比值比，1.20；95%置信区间，1.03 - 1.40；p = 0.02）。这些结果表明，与精神分裂症相关的季节性早期环境风险因素主要在城市地区起作用。
