一种参与酸感应的质子门控阳离子通道。

A proton-gated cation channel involved in acid-sensing.

作者信息

Waldmann R, Champigny G, Bassilana F, Heurteaux C, Lazdunski M

机构信息

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France.

出版信息

Nature. 1997 Mar 13;386(6621):173-7. doi: 10.1038/386173a0.

DOI:10.1038/386173a0

PMID:9062189

Abstract

Acid-sensing is associated with both nociception and taste transduction. Stimulation of sensory neurons by acid is of particular interest, because acidosis accompanies many painful inflammatory and ischaemic conditions. The pain caused by acids is thought to be mediated by H+-gated cation channels present in sensory neurons. We have now cloned a H+-gated channel (ASIC, for acid-sensing ionic channel) that belongs to the amiloride-sensitive Na+ channel/degenerin family of ion channels. Heterologous expression of ASIC induces an amiloride-sensitive cation (Na+ > Ca2+ > K+) channel which is transiently activated by rapid extracellular acidification. The biophysical and pharmacological properties of the ASIC channel closely match the H+-gated cation channel described in sensory neurons. ASIC is expressed in dorsal root ganglia and is also distributed widely throughout the brain. ASIC appears to be the simplest of ligand-gated channels.

摘要

酸感应与伤害感受和味觉转导都有关联。酸对感觉神经元的刺激尤其令人关注，因为酸中毒伴随着许多疼痛性炎症和缺血性病症。酸所引发的疼痛被认为是由感觉神经元中存在的H⁺门控阳离子通道介导的。我们现已克隆出一种H⁺门控通道（酸感应离子通道，ASIC），它属于对氨氯地平敏感的Na⁺通道/退化素离子通道家族。ASIC的异源表达诱导出一种对氨氯地平敏感的阳离子（Na⁺＞Ca²⁺＞K⁺）通道，该通道会被细胞外快速酸化短暂激活。ASIC通道的生物物理和药理特性与感觉神经元中所描述的H⁺门控阳离子通道紧密匹配。ASIC在背根神经节中表达，并且在整个大脑中也广泛分布。ASIC似乎是最简单的配体门控通道。