使用选择性5-羟色胺3（5HT3）受体拮抗剂（昂丹司琼）预防大剂量化疗所致呕吐的初步经验。
Preliminary experience with use of a selective 5HT3 receptor antagonist (ondansetron) to prevent high dose chemotherapy induced emesis.
作者信息
Parikh P M, Shah S R, Shah S C, Sheth V, Patel R A, Shah K C, Jain P K
机构信息
Sir Hurkisondas Narrotumdas Hospital, Padmashree Gordhanbapa Chowk, Mumbai, India.
出版信息
Indian J Cancer. 1996 Mar;33(1):17-20.
PMID:9063013
Abstract
Ondansetron was used as an antiemetic along with dexamethasone during 16 cycles of highly or moderately ematogenic chemotherapy. There was major control in two cycles and complete control in the remaining 14. Side effects were minor and did not require discontinuation of the drug. This combination, therefore, appears to be safe and effective in preventing chemotherapy induced emesis.
摘要
在16个周期的高度或中度致吐性化疗中，昂丹司琼与地塞米松一起用作止吐药。2个周期达到主要控制，其余14个周期达到完全控制。副作用轻微，无需停药。因此，这种联合用药在预防化疗引起的呕吐方面似乎是安全有效的。
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