Kumar S, Kulkarni S K
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Indian J Exp Biol. 1996 May;34(5):431-5.
Effect of antidepressant drugs (amitriptyline, imipramine and fluoxetine) on cognitive functions, impaired by the muscarinic antagonist scopolamine were investigated in mice. The changes in learning and memory tasks were studied using transfer latency on elevated plus maze and employing number of descents in passive avoidance paradigms. Amitriptyline and imipramine showed significant memory impairment. They also potentiated scopolamine-induced memory deficit in a significant way. Amitriptyline and imipramine impair cognitive function possibly due to their anticholinergic properties. Fluoxetine, a newer antidepressant, however showed no effect on learning and memory. It significantly reversed the scopolamine-induced memory impairment in both the tests. Fluoxetine with no anticholinergic property may prove to be a better drug in endogenous depression in elderly patients.
在小鼠中研究了抗抑郁药（阿米替林、丙咪嗪和氟西汀）对由毒蕈碱拮抗剂东莨菪碱所致认知功能损害的影响。使用高架十字迷宫上的转移潜伏期以及被动回避范式中的下降次数来研究学习和记忆任务的变化。阿米替林和丙咪嗪表现出显著的记忆损害。它们还以显著方式增强了东莨菪碱诱导的记忆缺陷。阿米替林和丙咪嗪可能因其抗胆碱能特性而损害认知功能。然而，较新的抗抑郁药氟西汀对学习和记忆没有影响。在两项测试中，它都显著逆转了东莨菪碱诱导的记忆损害。没有抗胆碱能特性的氟西汀可能被证明是老年患者内源性抑郁症的更好药物。
