Yano S, Sone S
Third Dept. of Internal Medicine, University of Tokushima School of Medicine.
Gan To Kagaku Ryoho. 1997 Feb;24(4):489-94.
Metastasis is the major obstacle in cancer therapy. Lung cancer is divided into 4 histological groups, such as small cell carcinoma, squamous cell carcinoma, adenocarcinoma and large cell carcinoma, representing different clinical behaviors. Novel metastasis models of human lung cancer cells to the liver, kidneys and lymph nodes were established in SCID mice depleted of NK cells. In the model under study, small-cell carcinoma cells mainly formed lymph-node metastases, while squamous cell carcinoma cells mainly metastasized to the liver and kidneys. Moreover, adenocarcinoma cells formed lung metastases and malignant pleural effusion. These findings suggest that our model reflects clinical behavior of metastatic lung cancer and is useful for evaluation of antimetastatic modalities.
转移是癌症治疗中的主要障碍。肺癌分为4个组织学类型，如小细胞癌、鳞状细胞癌、腺癌和大细胞癌，它们代表不同的临床行为。在缺乏NK细胞的SCID小鼠中建立了人肺癌细胞转移至肝脏、肾脏和淋巴结的新型转移模型。在本研究的模型中，小细胞癌细胞主要形成淋巴结转移，而鳞状细胞癌细胞主要转移至肝脏和肾脏。此外，腺癌细胞形成肺转移和恶性胸腔积液。这些发现表明，我们的模型反映了转移性肺癌的临床行为，可用于评估抗转移方法。
