Wu T, Chu N S
Department of Neurology, Chang Gung Medical College, Taipei.
J Formos Med Assoc. 1996 Feb;95(2):157-61.
Motor and somatosensory pathway functions were studied using motor evoked potentials (MEPs), somatosensory evoked potentials (SEPs) and F-wave responses in a woman with vitamin B12 deficiency. Initial evaluation before treatment revealed: 1) prolongation of central motor conduction to both the upper and lower limbs, and prolongation of peripheral conduction to the lower limbs; 2) prolongation of central conduction time to median nerve stimulation and absence of cortical SEPs to tibial nerve stimulation; and 3) prolongation of F-wave responses to tibial and peroneal nerve stimulation. After 11 months of treatment with hydroxocobalamin, follow-up studies disclosed: 1) normalization of central motor conduction to the upper limbs, peripheral motor conduction to the lower limbs and improvement of central motor conduction to the lower limbs; 2) normalization of central conduction time to median nerve stimulation but persistent absence of cortical SEPs to tibial nerve stimulation; and 3) normalization of F-wave responses. These data suggest that both central and peripheral conductions of motor and somatosensory pathways may respond to hydroxocobalamin therapy, and that MEPs are useful in the early detection of central and peripheral motor pathway function recovery following treatment with vitamin B12 deficiency.
在一名维生素B12缺乏的女性中，使用运动诱发电位（MEP）、体感诱发电位（SEP）和F波反应研究了运动和体感通路功能。治疗前的初始评估显示：1）上肢和下肢的中枢运动传导延长，下肢的外周传导延长；2）正中神经刺激的中枢传导时间延长，胫神经刺激时皮质SEP缺失；3）胫神经和腓总神经刺激的F波反应延长。使用羟钴胺治疗11个月后，随访研究发现：1）上肢中枢运动传导正常化，下肢外周运动传导正常化，下肢中枢运动传导改善；2）正中神经刺激的中枢传导时间正常化，但胫神经刺激时皮质SEP仍持续缺失；3）F波反应正常化。这些数据表明，运动和体感通路的中枢和外周传导可能对羟钴胺治疗有反应，并且MEP有助于早期检测维生素B12缺乏治疗后中枢和外周运动通路功能的恢复。
