Blidi M, Gatefosse M, Barjonnet G, Bedoucha J S, Wajcner G
Department of Internal Medicine, Orthopedic Surgery B, Rene Arbeltier Hospital, Coulommiers, France.
Rev Rhum Engl Ed. 1996 Jan;63(1):62-4.
A case of epidermoid carcinoma of the femur that arose in an area affected with chronic osteomyelitis for over 40 years is reported. The incidence of this rare complication has been estimated at 0.23% to 1.6% of all cases of chronic osteomyelitis. Although cases of sarcoma, adenosarcoma, plasmocytoma, and malignant fibrous histiocytoma have been reported, epidermoid carcinoma is the most common cancer type. This tumor develops after 20 to 40 years of chronic infection with a discharging fistula. Epithelialization of the fistulous tract has been demonstrated. The cancer arises in the metaplastic epithelium and can secondarily spread to the bone. Despite the low grade of malignancy of many of these epidermoid carcinomas, pulmonary metastases are not rare. Amputation meeting criteria for oncologic surgery is the only means of ensuring a good prognosis.
报告了一例发生于慢性骨髓炎长达40多年的股骨表皮样癌病例。这种罕见并发症的发生率估计在所有慢性骨髓炎病例的0.23%至1.6%之间。虽然已有肉瘤、腺肉瘤、浆细胞瘤和恶性纤维组织细胞瘤病例的报道，但表皮样癌是最常见的癌症类型。这种肿瘤在伴有引流瘘管的慢性感染20至40年后发生。已证实瘘管发生上皮化生。癌症起源于化生上皮，可继发扩散至骨骼。尽管许多这类表皮样癌的恶性程度较低，但肺转移并不罕见。符合肿瘤外科手术标准的截肢是确保良好预后的唯一手段。
